Khairpur Medical College, Khairpur Mirs was established and inaugurated by Honorable Chief Minister of Sindh, Syed Qaim Ali Shah on 29th December 2012 in Elementary college Khairpur Mirs. Initially with name of LUMHS Khairpur Medical College, Khairpur Mirs as a part of Liaquat University of Medical & Health Sciences, Jamshoro. Later on, the name of college was changed to Khairpur Medical College, Khairpur Mirs as Project of Government of Sindh. Presently, there are 12 public sector Medical Colleges in Sindh including KMC Khairpur. The College was recognized by Pakistan Medical & Dental Council, Islamabad for 100 MBBS seats in 2015 and re recognized & registered by Pakistan Medical Commission /HEC Islamabad in january 2020 After recognition, first batch of 100 students was admitted for session 2014-15 who have graduated in March 2020. The PM&DC curriculum is adopted and modular system of examination is started from 2022 according to syllabus of PUMHS-Nawab Shah(SBA). There is system of counseling and continuous internal assessment to help students and teachers abreast with learning and simultaneous self-evaluation.